Supplement Stack
34 compounds targeting longevity at the systems level
Systems Targeted
Mitochondrial biogenesis + efficiency
NMN, PQQ, Shilajit, Carnitine
Autophagy & senescent cell clearance
Spermidine, Fisetin, fasting
Inflammation & vascular health
Olive leaf, omega-3s, quercetin
Muscle + VO2 preservation
Creatine, HMB, Turkesterone
Epigenetic & metabolic stability
AKG, metformin, methylation support
Gut & Immune Foundation
Probiotics (B. subtilis DE111 + Lactobacillus strains)
Strengthens gut barrier, improves immune signaling, lowers chronic inflammation — a core driver of biological aging.
Core Longevity / Aging Biology
Taurine
Declines with age; improves mitochondrial efficiency, insulin sensitivity, blood pressure, and lifespan markers.
NMN
Raises NAD+ — better mitochondrial output, DNA repair, sirtuin activation.
Fisetin
Senolytic activity (reduces senescent cell burden) and suppresses inflammatory SASP signaling.
Quercetin
Anti-inflammatory, antioxidant, senolytic synergist; improves endothelial and immune health.
Spermidine
Potent autophagy inducer — one of the strongest human-associated longevity compounds.
TMG (Trimethylglycine)
Supports methylation and homocysteine control, especially important with NMN and metformin.
Creatine Monohydrate
Preserves muscle and brain energy buffering; strongly linked to healthspan and mortality reduction.
Glycine
Collagen synthesis, glutathione production, sleep quality; higher intake associated with lower mortality.
Astaxanthin
Mitochondria-targeted antioxidant; protects lipids, skin, eyes, and exercise recovery without blunting hormesis.
PQQ (Pyrroloquinoline Quinone)
Mitochondrial biogenesis signaling, improves mitochondrial efficiency and oxidative resilience.
Brain & Cognitive Longevity
Lion's Mane Mushroom
Stimulates NGF; supports neuroplasticity and long-term cognitive resilience.
Magnesium L-Threonate
Raises brain magnesium levels; improves memory, learning, and sleep architecture.
Stress, Hormones & Cellular Signaling
Ashwagandha
Lowers cortisol, improves sleep and stress resilience — chronic stress accelerates aging.
Tongkat Ali
Improves testosterone:cortisol ratio, motivation, metabolic and muscle health.
Maca (High Strength)
Adaptogenic endocrine support; improves energy, mood, libido.
Shilajit (Purified, Standardized)
Fulvic acid + trace minerals — mitochondrial electron transport support, ATP production, testosterone signaling.
Turkesterone
Ecdysteroid that enhances muscle protein synthesis and recovery without androgenic effects — supports lean mass longevity.
Vascular, Immune & Metabolic Protection
Olive Leaf Extract (40% Oleuropein)
Anti-inflammatory, antimicrobial, insulin-sensitizing polyphenol; improves endothelial function and blood pressure.
Beet Root Extract (with Black Pepper)
Nitric oxide production — vascular health, brain perfusion, endurance.
Forskolin
Raises cAMP — fat metabolism, cellular signaling, lean mass preservation.
Minerals & Micronutrient Defense
USANA Key Minerals
Ensures enzymatic and mitochondrial mineral sufficiency (often a hidden longevity limiter).
USANA Vita Antioxidant
Broad polyphenol and micronutrient coverage to control oxidative damage without suppressing adaptive stress responses.
Calcium AKG
Alpha-ketoglutarate supports epigenetic regulation, stem cell function, inflammation control.
Magnesium Malate
Supports mitochondrial energy and muscle recovery (Krebs cycle intermediate).
Magnesium Glycinate
Nervous system regulation, insulin sensitivity, deep sleep quality.
Performance & Muscle Preservation
HMB
Prevents muscle breakdown; sarcopenia prevention is one of the strongest predictors of lifespan.
L-Carnitine
Fatty acid transport into mitochondria; metabolic flexibility and endurance.
Lipids, Hormones & Bone
Ultra Omega Fish Oil
Reduces inflammation, improves cardiovascular and brain health; corrects omega-3 deficiency signals.
Vitamin D (D3)
Immune modulation, bone density, hormone regulation, cardiovascular protection; low levels strongly correlate with all-cause mortality.
Medical / Metabolic Longevity
Metformin
Activates AMPK, improves insulin sensitivity, lowers cancer and mortality risk signals in humans.
Lutein
Protects eyes and brain; linked to cognitive processing speed and neuroprotection.
Circadian, Sleep & Fasting Support
Melatonin (4 mg on fasting nights)
Circadian alignment, mitochondrial antioxidant, enhances autophagy and DNA repair during fasting.
Vitamin B12 (morning)
Methylation and neurological protection — essential with metformin and plant-forward diet.